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Unlike prior reviews, which often present descriptive overviews, this article emphasizes comparative evaluation of design principles, biological mechanisms, and translational hurdles, including biosafety, tumor heterogeneity, and large-scale manufacturability

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Adjusting protocols based on results When to extend protocol Extend if : Making progress but not complete (60-70% healed, goal is 90%) Results plateaued but could improve with more time No side effects, tolerating well Can afford extension How to extend : Add 4-8 weeks to original timeline May need to order more supplies Continue same doses unless adjusting Example : Planned 8 weeks BPC-157 , at week 8 injury 70% healed

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